Transforming how molecular biology
translates to human health, personalized
medicine and synthetic biology.

our history
DNA Script believes in engineering biology to accelerate breakthroughs in life science and human health.
DNA Script was created to revolutionize DNA write with enzymes. Our core R&D efforts have produced innovations in enzyme engineering, surface and nucleotide chemistries, and instrumentation.  The integration of these innovations has resulted in SYNTAXTM, the world’s first benchtop DNA printer powered by enzymatic technology. With continued advancement and innovation, we believe DNA Script’s enzymatic DNA synthesis technology is poised to become the engine of genomics research as well as personalized medicine. 
our team

We’re science-driven thinkers, makers, dreamers and do-ers.

Founders
Thomas Ybert, PhD Co-Founder and CEO
Sylvain Gariel Co-Founder and COO
Xavier Godron Co-Founder and CTO
Meet the DNA Script team
See full team directory
Board Members
Thomas Ybert, PhD Co-Founder and CEO
Sylvain Gariel Co-Founder and COO
Joachim Rothe LSP
Nick Naclerio Illumina Ventures
Josko Bobanovic Sofinnova Partners
Philippe Peltier Kurma Partners
Paul MacEwan Independent Board Member
Heiner Dreismann Independent Board Member
Laurent Higueret Board Observer
Joey Mason Board Observer
our partners
lspvc-logo
illumina-ventures
sofinnova-logo
bpi-france-logo
m-ventures
kurma-partners-logo
idinvest-logo
easme-logo
institut-pasteur-logo
la-french-tech-logo
agoranov-logo
Casdin Capital Logo – Transparent – Large
Danaher
Agilent
values
We’re looking for great individuals who are committed to our company values.

Excellence

Take responsibility for your work. Aim to act, do and behave with the goal of reaching the unreachable.


Transparency

Give sincere, reliable and trustworthy information. Bring objective facts, no matter how they look.


Benevolence

Create a positive environment for everyone. Be supportive to the team, the company and your colleagues.

careers
We are synthesizing a technology revolution. Join us.
General & Administration

Opportunity and Challenges

We are looking to assemble a team of best-in-class, innovative and passionately impatient people.  We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”.  We offer the opportunity of joining a dynamic, international, and highly skilled team in a pioneering startup. Our SYNTAX DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have a far-reaching impact across biological sciences.    

The Role

We are looking for an experienced Sales and Market Developer who can own the migration and maturation of our instrument evaluation program into a sale.   We need a pathfinder and a technical evangelist.   Boots on the ground in the EU to manage our existing partners’ pre-commercial success into becoming customers, as well as finding new partners.  An individual with experience in sales and the market development aspects associated with building mind share for a new technology in the EU.  We need a commercial presence to be built, and executed upon; we need a leader who can help us build and deliver for the region.  Ideally, this individual would have experience leading in market development and in sales efforts in the EU. This is a critical role on the Commercial team that requires collaboration with team members in Marketing, Sales, Product Development and senior management. We’re looking for a leader who can ensure the elements of our brand are embodied in all of the different ways that customers in the EU will interact with our products, goods and services.

Responsibilities

  • Be the commercial face of our Syntax EDS system during evaluation and through product launch in the European market.  Meet our existing partners, understand them, and their needs well enough to find new partners who have the same needs.
  • Work with the Global Head of Sales to deliver on our channel strategy.
  • Lead prospecting and opportunity funnel seeding in the EU.  Unify the needs of the sales team and marketing team early in the program and transition that success into commercial success.
  • Collaborate to construct regional campaigns to accelerate adoption of our platforms through strong partnerships with research and development,  product management, and  sales. Move to execute in the EU.
  • Collaborate with Product Management and Applications to develop and produce educational materials for market outreach & expansion within the EU.
  • Own EU regional  execution on corporate messaging and marketing activities across all media channels

Requirements

  • Have a passion for commercializing platforms that are at the leading-edge & accelerating innovation in life science
  • Demonstrated experience in global product launches or specific programs and campaigns to translation of commercial strategy into commercial success.
  • Strong experience in the technical evangelism necessary to secure high success early adopters and their conversion into buying customers with innovative technologies in the life sciences tools market.
  • Demonstrated acumen as a creative thinker; help establish and build this new frontier.  Not afraid to re-draw the box, etc.
  • Ability to listen to customers and convert complex technical concepts into crisp messages on benefits for, then use those needs for prospecting.
  • Effectiveness in building relationships with key stakeholders necessary for collaboration at all levels and influence without authority. Gain alignment and achieve results by power of influence.
  • BA/BS degree in Biological Sciences
  • 5+ years of marketing and or sales experience in a similar position within the life science industry.
  • Strong communication skills are required for this role: both written and verbal communication. Demonstrated by the ability to present technical presentation in for sales/sales training, and for small groups and customers.
  • Ability to travel up to 50% domestic and international.

Preferably

  • Start-up mind-set is strongly preferred.
  • Experienced across the Marketing continuum; formal training (MBA) a plus
  • Understanding of the new product introduction and product lifecycle management processes
  • Multilingual and multicultural- help across the EU
  • Key account management experience a plus

Miscellaneous

  • Job location:EU, with a preference for Paris France
  • Requires travel among DNA Script corporate offices and client sites throughout US and Europe.
  • Start date: Q1 2020

Contact : kfe@dnascript.co

Apply now

Opportunity and Challenges

We are looking to assemble a team of best-in-class, innovative and passionate people.  We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”.  We offer the opportunity of joining a dynamic, international, and highly skilled team in a pioneering startup. Our same-day DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences.    

The Role

We are looking for an experienced Senior Software and Hardware Product Manager who will be accountable for leading our product strategy (appropriate for the life sciences/biotech industry) and for driving product requirements. Key responsibilities include translating customer insights and feedback into actionable requirements to guide technical development into differentiated products. Proven experience with the integration of software and hardware to provide a seamless solution for customers is ideal. The successful candidate will act as the primary point of contact for all products, and the conduit between customers and internal teams to help drive collaboration across the organization. This role is an integral part of the Product Management (PM) team at DNA Script and will report to Head of Product Management (PM).  

Responsibilities

  • Lead and manage all aspect of software and hardware product management from concept to development and launch, and lifecycle management through obsolescence.
  • Own SW strategy and software platform lifecycle, which includes defining software product roadmap for all software associated with/required for DNA Script systems (e.g. on-instrument software, LIMs software, data management, data analytics, cloud-base platform, access and storage solutions).
  • Represent the customer as PM lead in cross-functional core teams; provide customer requirements, guide feature specifications, and make decisions about implementation and resource trade-offs in alignment with relevant stakeholders to ensure products meet user and business needs.
  • Drive the execution of product evaluation programs and act as the point of contact for customer escalations.
  • Lead and develop customer engagement programs for usability feedback. Actively seek Voice of Customer data from external and internal users to drive product improvements and new product initiatives.
  • Develop and deliver effective product presentations and training to Service and Support and Sales teams in as part of pre-sale activities and funnel management.
  • Own and craft field communications related to product releases, updates, and manage customer migrations throughout product lifecycle.

Requirements

  • 5+ years of product management and development experience and/or in a similar position within the life science/biotech fields.
  • A customer-centric mindset with technical software and hardware development knowledge is critical to success in this role.
  • First-hand experience with integrating software and laboratory automation, analytical instruments, reagents, and consumables – to deliver a seamless solution for life sciences customers.
  • Demonstrate success in leading technical teams to develop products that meet usability requirements, testing for product-market fit, and driving the project from concept to product launch.
  • Strong understanding of product lifecycle and software revision management; and how it affects the customer experience from launch to obsolescence.
  • Ability to influence and gain alignment among teams to achieve results – without direct authority.
  • Excellent team player. Comfort with ambiguity and ability to resolve.
  • Experience with troubleshooting, problem-solving, and driving software root cause analysis to resolution.
  • Exceptional written and verbal communication skills, as well as analytical, and project management skills.
  • Excellent speaker with technical presentation skills to small groups and customers.
  • BA/BS, Master’s, or PhD in Computer Science, Science or Engineering field – e.g. Biochemistry, Biotechnology, Mechanical or Electrical Engineering preferred, Bioinformatics or related field and equivalent practical experience.
  • Willingness and ability to travel up to 25% domestically and internationally.

Preferably

  • Start-up mind-set and experience in a startup environment is strongly preferred.
  • Experienced with managing third-party SW vendors
  • Experienced in and/or solid understanding of API integration

Miscellaneous

  • Job location: South San Francisco, US
  • Requires travel among DNA Script corporate offices and client sites throughout US and Europe.
  • Start date: Q4 2020
Apply now

Opportunity and Challenges

We are looking to assemble a team of best-in-class, innovative and passionately impatient people.  We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”.  We offer the opportunity of joining a dynamic, international, and highly skilled team in a pioneering startup. Our Next-Hour DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences.    

The Role

We are looking for an experienced Marketing Communications Manager/Sr. Manager who can own the integration of our brand and product messaging in communications across all media. This manager will have a strong focus on digital marketing to develop and drive a digital content roadmap that maximizes the reach of our products & services and delivers on our growth expectations. Ideally, this manager would have experience leading and transforming organizations to be more digitally focused. This is a critical role on the Commercial team that requires collaboration with team members in Marketing, Sales, Product Development and senior management. We’re looking for the leader who can ensure the elements of our brand are embodied in all of the different ways that customers will interact with our products, goods and services in all forms of communications.

Responsibilities

  • Lead and develop go-to-market plans for new products introductions by ensuring the consistency messaging and positioning, and coordinate execution across digital channels, sales training, and tradeshows.
  • Drive & execute marketing programs and campaigns to accelerate adoption of our platforms through strong partnerships with product management, applications, and sales.
  • Develop, budget, monitor, and evaluate the success of campaigns for optimization and continued effectiveness; determine ROI.
  • Formulate and drive digital strategy and content roadmap to transform and maximize reach, from ideation through execution and implementation.
  • Proactively identify, execute, and refresh content strategies to generate awareness, demand generation and improved customer experience and conversion.
  • Own and manage digital marketing assets; build a collateral portfolio for digital, virtual & print interactions.
  • Collaborate with Product Management and Applications to develop and produce educational materials for market outreach & expansion.
  • Own corporate messaging across all media channels.

Requirements

  • Have a passion for commercializing platforms that are at the leading-edge & accelerating innovation in life science.
  • Experienced in global product launches or specific programs and campaigns to support corporate & commercial strategy.
  • Have the drive and initiative to learn new skills and can demonstrate complete ownership of assigned marketing campaigns and programs.
  • Creative thinker and can help establish new frontiers in how we communicate with prospects, customers, investors, be unafraid to re-draw the box, etc.
  • Ability to convert complex technical concepts and product capabilities into crisp messages on benefits for the target audience in presentations & communication.
  • Effectiveness in building relationships with key stakeholders necessary for collaboration at all levels and influence without authority. Gain alignment and achieve results by power of influence alone.
  • BA/BS degree in marketing or equivalent preferably with background in Biological Sciences
  • 5+ years of marketing experience in a similar position within the life science industry.
  • Strong writing skills are required for this role, must demonstrate proven experience in writing digital content, technical writing, and/or copywriting.
  • Excellent communication skills with ability to present technical presentation in sales trainings, small groups and customers.
  • Ability to travel up to 25% domestic and international.

Preferably

  • Start-up mind-set is strongly preferred.
  • Experienced across the Marketing continuum.
  • Understanding of the new product introduction and product lifecycle management processes.
  • Account, vendor, or project management experience.

Miscellaneous

  • Job location: South San Francisco, US.
  • Requires travel among DNA Script corporate offices and client sites throughout US and Europe.
  • Start date: Q4 2020
Apply now

Opportunity and Challenges

We are looking to assemble a team of best-in-class, innovative and passionately impatient people.  We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”.  We offer the opportunity of joining a dynamic, international, and highly skilled team in a pioneering startup. Our Next-Hour DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences.    

The Role

We are looking for an experienced Marketing Communications Manager/Sr. Manager who can own the integration of our brand and product messaging in communications across all media. This manager will have a strong focus on digital marketing to develop and drive a digital content roadmap that maximizes the reach of our products & services and delivers on our growth expectations. Ideally, this manager would have experience leading and transforming organizations to be more digitally focused. This is a critical role on the Commercial team that requires collaboration with team members in Marketing, Sales, Product Development and senior management. We’re looking for the leader who can ensure the elements of our brand are embodied in all of the different ways that customers will interact with our products, goods and services in all forms of communications.

Responsibilities

  • Lead and develop go-to-market plans for new products introductions by ensuring the consistency messaging and positioning, and coordinate execution across digital channels, sales training, and tradeshows.
  • Drive & execute marketing programs and campaigns to accelerate adoption of our platforms through strong partnerships with product management, applications, and sales.
  • Develop, budget, monitor, and evaluate the success of campaigns for optimization and continued effectiveness; determine ROI.
  • Formulate and drive digital strategy and content roadmap to transform and maximize reach, from ideation through execution and implementation.
  • Proactively identify, execute, and refresh content strategies to generate awareness, demand generation and improved customer experience and conversion.
  • Own and manage digital marketing assets; build a collateral portfolio for digital, virtual & print interactions.
  • Collaborate with Product Management and Applications to develop and produce educational materials for market outreach & expansion.
  • Own corporate messaging across all media channels.

Requirements

  • Have a passion for commercializing platforms that are at the leading-edge & accelerating innovation in life science.
  • Experienced in global product launches or specific programs and campaigns to support corporate & commercial strategy.
  • Have the drive and initiative to learn new skills and can demonstrate complete ownership of assigned marketing campaigns and programs.
  • Creative thinker and can help establish new frontiers in how we communicate with prospects, customers, investors, be unafraid to re-draw the box, etc.
  • Ability to convert complex technical concepts and product capabilities into crisp messages on benefits for the target audience in presentations & communication.
  • Effectiveness in building relationships with key stakeholders necessary for collaboration at all levels and influence without authority. Gain alignment and achieve results by power of influence alone.
  • BA/BS degree in marketing or equivalent preferably with background in Biological Sciences
  • 5+ years of marketing experience in a similar position within the life science industry.
  • Strong writing skills are required for this role, must demonstrate proven experience in writing digital content, technical writing, and/or copywriting.
  • Excellent communication skills with ability to present technical presentation in sales trainings, small groups and customers.
  • Ability to travel up to 25% domestic and international.

Preferably

  • Start-up mind-set is strongly preferred.
  • Experienced across the Marketing continuum.
  • Understanding of the new product introduction and product lifecycle management processes.
  • Account, vendor, or project management experience.

Miscellaneous

  • Job location: Paris, France.
  • Requires travel among DNA Script corporate offices and client sites throughout US and Europe.
  • Start date: Q4 2020

Apply now

The role

DNA Script is looking for a talented patent attorney to join the legal department, in a role that is central and critical to support the development of the company.  The candidate will be responsible for (i) patent preparation and prosecution ; (ii) patent committee and idea sourcing ; and (iii) related and competitor IP monitoring. writing and filling patent applications, managing existing patent portfolio and track office actions, animating patent committee and monitoring new ideas and findings, monitoring competitive landscape and IP.

Responsibilities

  • Drafting and filling patent applications
  • Managing existing patent and applications portfolio, maintaining internal docket and track office actions
  • Overseeing IP advisors and outside patent attorneys involved in patent prosecution
  • Managing inventorship and ensuring proof of ownership of the company invention via assignments
  • leading and organizing patent committees and new invention related processes
  • Monitoring new ideas and finding generated by the organization
  • Organizing and lead the interaction with innovating stakeholders in the Company to gather new ideas and findings
  • Track and follow operational team work related to patent filling and prosecution
  • Monitoring competitive landscape and IP
  • Conduct freedom-to-operate studies on regular basis or on ad-hoc requests
  • Conduct IP landscape analysis as requested by management or operational activities
  • Sensitize and train operational teams on importance and processes of IP
  • Manage internal communication on IP related activities
  • Provide legal help/support with general agreements and contract upon requests

Qualifications and experience

Essential

  • Has a Juris Doctorate or equivalent
  • Has an advanced degree in Molecular Biology, Bioengineering, Molecular Genetics, Synthetic Biology, Microbiology,  or a related biotechnology-relevant discipline or an advanced degree in Organic Chemistry, Nucleic Acid Chemistry or related biochemistry-relevant discipline.
  • Cumulate 3-5 years of total prior legal experience including time at a top-tier law firm and/or pharmaceutical or biotechnology industries
  • Proven track record in drafting and prosecuting biotechnology-related patent applications
  • Experience in working with research and development teams and environment
  • Experience in managing, organizing or taking part in IP committee or relevant processes
  • Possess working knowledge of transactional, commercial, and intellectual property law
  • Can handle large volume of work on a prioritized basis
  • Has exceptional attention for detail and accuracy abilities. As well as the ability to set a course that is optimal for the company in the context of both ambiguity and complicated and conflicting priorities.
  • Strong interactive skills and collaborative attitude to work effectively in a team environment
  • Has excellent organizational, project management and problem-solving skills with the ability to ensure to stay in budget and time while communicating clearly to the rest of the management team.
  • Has the highest levels of personal honesty, integrity and commitment.

Desirable

  • Experience in the field of DNA such as DNA synthesis or DNA sequencing
  • Start-up/small company experience
  • International and preferably US experience or work for a US firm

Miscellaneous

  • Job located in Kremlin-Bicêtre (Paris area)
  • Start date: ASAP

Contact

vb@dnascript.co ; ty@dnascript.co

Apply now

The role

Lead the intellectual property function of the company, including counselling management on IP matters, overseeing and reviewing preparation and prosecution of patent applications, IP risk assessment and management, reviewing IP-related provisions of corporate contracts, and staff IP education.

Responsibilities

Intellectual property strategic guidance and counsel

  • Propose and implement IP strategy in line with Company’s business strategy and to ensure Company dominant IP position for the long term
  • Propose and manage in-licensing strategy to ensure Company dominant IP position for the long term
  • Provide high level, independent support for due diligence, strategic collaborations, licensing agreements and other business contracting needs
  • Provide opinion and recommendation to management on IP strategy and related activities

Patent strategy

  • Managing patents claims and filling strategy to unsure best strength, scope and position of patent portfolio to ensure long-term competitive advantage
  • Oversee and review of patent preparation and prosecution to maximize value of portfolio
  • Maintain positive relationships with external counsel and experts.
  • Recommend and help implement IP strategies for R&D project teams
  • Educate and advise senior management & scientists on important IP issues and advance IP/patent awareness.

Management and reporting of all intellectual property functions

  • Manage all IP related function and team
  • Build, manage and monitor IP functions and activities budget
  • Contribute to Company Board reporting and take part of Board meeting
  • Report and communicate internally IP activities on a regular basis

IP risk monitoring, litigation and associated strategy

  • Manage and support outside counsel in IP disputes, litigation, IPRs, PGRs and oppositions, including formulating appropriate IP litigation strategies
  • Develop a thorough understanding of DNA Script‘s current and planned business activities, programs, competitors, and markets and keep abreast of developing legal trends, laws and regulations.
  • Review publications, presentations, press releases and other materials for clearance.
  • Conduct or supervise freedom-to-operate, non-infringement, and competitive landscape analyses in key technology areas and product development

Qualifications and experience

Essential

  • JD, registered patent attorney
  • 12+ years of relevant IP experience in the life-science industry, including significant in-house experience.
  • An advanced degree in Molecular Biology, Bioengineering, Molecular Genetics, Synthetic Biology, Microbiology, or a related biotechnology-relevant discipline or an advanced degree in Organic Chemistry, Nucleic Acid Chemistry or related biochemistry-relevant discipline.
  • Direct experience in biologic patents and life-science tool product and product development
  • Experience in managing, organizing or taking part in IP committee or relevant processes
  • Possess working knowledge of transactional, commercial, and intellectual property law
  • Experience in Board reporting and Board meeting preparation and participation
  • Can handle large volume of work on a prioritized basis
  • Exceptional attention for detail and accuracy abilities.
  • Strong interactive skills and collaborative attitude to work effectively in a team environment
  • Excellent organizational, project management and problem-solving skills with the ability to ensure to stay in budget and time while communicating clearly to the rest of the management team.
  • Highest levels of personal honesty, integrity and commitment.

Desirable

  • Experience in the field of DNA technology, such as DNA synthesis or DNA sequencing
  • Start-up/small biotechnology company experience
  • International experience with or for non-US firms

Miscellaneous

  • Job located in South San Francisco (Bay area)
  • Start date: ASAP

Contact

vb@dnascript.co ; ty@dnascript.co

Apply now
Manufacturing Operations

Opportunity and Challenges

We are looking to assemble a team of best-in-class, innovative and passionate people.  We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”.  We offer the opportunity of joining a dynamic, international and highly skilled team in a pioneering startup. Our Next-Hour DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

DNA Script is actively searching for a Manufacturing & Procurement Technician who will be primarily responsible for the preparation of kits under good laboratory practices. This role will include inventory follow up, execute products preparation to build the kits with full traceability and interact with R&D teams to support customer demands. In addition, she/he will be responsible for procurement of all necessary items for kits production.

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences.    

The position will be US based, in the South San Francisco, California office.

Responsibilities

  • Maintain inventory for laboratory and manufacturing operations @ SSF site
  • Maintain finished goods inventory, work in process and raw materials; recommend material orders as needed to maintain stocks for production
  • Monitor, qualify,  and maintain calibration of laboratory instrumentation used for manufacturing
  • Participate in planning activities pertaining to kit production
  • Use approved analysis techniques to characterize and ensure quality of synthesis reagents and products
  • Perform / assist with daily oligosynthesis operations and provide feedback to development
  • Perform reagent manufacturing, logistics planning and other tasks as necessary in a laboratory environment
  • Prepare buffers, solutions, and other kit components following approved protocols, including the use and safe handling of hazardous chemicals, data input and record keeping
  • Work with supply chain and logistics to optimize packaging and shipments, eliminating back orders
  • Assist in assembly and packaging of reagents and consumables for both domestic and international shipment
  • Procure and receive materials to support kit production and shipping
  • Execute tasks under approved SOPs, document production using batch records and contribute to improving overall quality in operations
  • Contribute to development and execution of incoming inspection of received goods and stability tests
  • Work under the supervision of Product Development and Supply Chain management

Experience

  • Bachelors degree in Biology, Biochemistry, Chemistry or related field.
  • 1-3 years of relevant experience is preferred
  • Experience working in laboratory
  • Experience working under GLP (Good Laboratory Practices) and following good documentation and compliance practices
  • Experience with laboratory safety procedures and documentation
  • Detail oriented and meticulous attention to detail
  • Willingness to take/accept new responsibilities and able to work with minimal supervision.
  • Demonstrated ability to work in multidisciplinary teams

Miscellaneous

  • Job located in South San Francisco
  • Start date: Q4 2020

Contact: jal@dnascript.co

Apply now

The role

We are looking for a Purchasing Manager to support our Manufacturing Operations team, for inventory and non-inventory items ! The ideal candidate will be responsible for secure the supply contracts of key suppliers, negotiate purchase conditions, implement supplier agreements, manage cost reduction while continuing to ensure quality of purchased products and improve supplier performance. He will also be supporting the suppliers analysis and supplier audit process in coordination with Quality Assurance Manager.

The candidate will also have experience in managing capital expenditure on many projects going on.

Responsibilities

•             Analyze data or insights to determine industry and market trends

•             Negotiate purchase conditions and contracts with vendors (price, schedule, quality, and terms) on the defined portfolio

•             Implement and manage supplier agreements

•             Execute strategies and tactics to achieve best results regarding pricing, logistics, inventory, and payment terms

•             Analyze impact to determine the best value supplier

•             Devise long-term strategies aimed to reduce raw material landed costs while satisfying a continuous and steady supply

•             Study and propose real back-up and second source strategy (product group, regional …)

•             Manage International Supplier Relationships and foster trust relationships with vendors to achieve better pricing and quality of services

•             Support and assist other departments to ensure efficient flow of purchasing transactions throughout the company

•             Scout and present alternate raw materials and new technological solutions

•             Assume responsibility of budget development

•             Report periodically summary results and defined KPIs to head of Manufacturing Operations

Qualifications and experience

•             Bachelor’s degree in Business Administration and a minimum of 3 years of relevant experience in the field

•             Knowledge of MRP/ERP software required (NetSuite / Oracle)

•             Ability to work under pressure

•             Good judgment in price negotiation and vendor selection

•             Decisive and excellent problem-solving skills

•             Strong analytical skills

•             Ability to plan, organize, and manage multiple projects with attention to detail

•             Ability to handle changing priorities under tight deadlines

•             Fluent English speaking required as some key suppliers are based in the USA

Miscellaneous

•             Job located in Kremlin-Bicêtre (Paris area)

•             Start date: ASAP

Contact: cma@dnascript.co

Apply now
Product Development

The role

We are looking to assemble a team of best-in-class, innovative and passionate people.  We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”.  We offer the opportunity of joining a dynamic, international and highly skilled team in a pioneering startup. Our Next-Hour DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

DNA Script is actively searching for an accomplished Field Service Engineer to support our partners and customers in their use and application of DNA Script’s commercial product. 

The individual will be responsible for leading complex technical inquiries in the field including troubleshooting and repairs, coordinating customer feedback and interactions, and representing user experiences within the company to aid development of next generation products. 

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences.    

The position will be based in Paris.

Responsibilities

  • Installs and optimizes hardware/software/network products and configurations at customer sites.
  • Diagnoses and resolves product performance problems.
  • Performs maintenance and repairs
  • Ensures customer satisfaction by advising customers on preventive maintenance and configurations, which may impact product performance.
  • Proactively responds to potential equipment issues to prevent unplanned interruption of customers’ business.
  • Delivers fully integrated solutions, which may include peripherals, communications, operating systems and applications software.
  • Trains other field engineers and customers in the company’s system products. 
  • Provides user-oriented and service-related  input to ongoing and new development projects.

Experience

  • Bachelors within the science field — e.g. biomedical engineering,  analytical biochemistry, biotechnology or similar is highly preferred
  • 4+ years of experience in a similar position and/or experience as an end-user of analytical instrumentation

Ideal Candidate will have

  • Experience or expertise with Laboratory Automation solutions (eg. pipetting robots, electronics and linear actuators) and systems involving reagents and consumables
  • Experience with troubleshooting and problem solving Customer service and solutions-oriented, with capability to precisely document issues, root cause analyses, troubleshooting experimentation and resolutions/repairs.
  • DNA Synthesis Experience, or Utilization of Synthetic Oligos in a biochemical application.
  • Excellent written and verbal communication skills
  • Ability to travel extensively including overnight travel as dictated by business needs

Miscellaneous

  • Remote Job based in Paris (France). Requires 75% travel to corporate offices and client sites throughout EU countries.
  • Start date: Q3 2020
Apply now

The role

Become part of our Product Development team and help us to design and conduct feasibility studies investigating and optimizing the interactions among reagents, consumables, hardware and protocols.  You will be able to use statistical methods to evaluate data, identify trends and make clear recommendations based on data.  You will interface with a cross-functional project team to ensure alignment with design requirements and that the product meets approved quality standards.  You will maintain detailed documentation throughout all phases of product development, and provide technical input for FMEAs, risk mitigation strategies and designs.

Responsibilities

•             Assay characteristics of reagents and consumables, including both objective and performance criteria

•             Troubleshoot hardware and software protocols and sources of variability derived from both reagents and consumables

•             Formulate test batches of reagents for experimental use and performance characterization.

•             Contribute to formulation of production lots of reagents following defined Work Instructions and completing batch records

•             Perform acceptance tests on production batches of reagents and consumables

•             Preparation of specific reagents and consumables for daily experimentation and performance characterization 

•             Analyze data using analytical tools (e.g., Excel, Python, R, ImageJ), documenting and presenting results to the team

•             Create, track, monitor, and report metrics and key performance indicators for DNA Script instrument systems

•             Perform system and subsystem verification and validation protocols

•             Manage reagent stability study design, and execution.  Investigate alternate materials to enhance reagent stability and/or improve system design/performance

•             Troubleshoot and optimize fluidic dispense systems, thermal control systems and related subsystems.  Develop and document acceptance / verification tests as required.

•             Complete documentation to support testing procedures including data capture, forms, logbooks, and inventory batch records

•             Define and develop performance-oriented feasibility studies for procedure improvements and newly implemented capabilities within the context of prototype development and improvement of finished products

•             Execute and report the results of end-to-end experimental runs, including oligo  design, run setup, observation of runs-in-progress, performance of a variety of molecular QC assays (qPCR, gel electrophoresis, NGS), data analysis and reporting of single data sets or trends across long term studies. 

Experience

•          BS in Biological Sciences or Engineering with 5+ years of experience in the Life Science and laboratory automation domain

•          Strong skills in laboratory and system feasibility experimentation and Verification and Validation execution, Data Analysis, representation, and presentation, reagent formulation and GLP/GMP documentation.   •             Desire and ability to work in a small interdisciplinary team to develop new technologies at a rapid pace

Ideal Candidate will have

•             Experience in regulated Life Science product/medical device development under design controls is preferred

•             Knowledge of liquid handling and laboratory automation, microfluidics, molecular assay and QC techniques, and reagent and platform manufacturing techniques is preferred.

•             Demonstrated problem-solving and troubleshooting skills along with strong verbal and written communications

•             Organized and detail oriented

•             Ability to work in a team environment

Miscellaneous

  • Job located in South San Francisco
  • Start date: Q3 2020
  • Contact: cdm@dnascript.co
Apply now
Research & Development

The role

DNA Script is looking for a dynamic and talented individual to join the System Integration team, in charge of the development of DNA synthesis process and instrumentation.

Enzymatic synthesis of an oligonucleotide is a cyclic process, based on a one by one addition of nucleotides by a DNA polymerase that requires no DNA template. This iterative process needs to be automated in a robust, reliable, and precise way to achieve high quality synthesis.

The role will be to lead the development and optimization of enzymatic DNA synthesis process, a core activity of the company. The candidate will rigorously conduct development studies to enhance the quality of DNA Script oligos in terms of purity, quantity, and functionality. He or she will be fully responsible for an automated platform dedicated to synthesis development activities, ensuring its functioning and continuous improvement. The candidate must be handy and a quick learner to accurately grasp the subtilities of the technology, and efficiently troubleshoot automated systems. The candidate will be in charge of training and managing a technician. The position will require a lot of transversal and interdisciplinary communication with the different teams.

This offer is a great opportunity to join a rapidly growing company and to participate in the development of a new and revolutionary technology that will have far-reaching impact across biological sciences.

Responsibilities

Your missions will be:

  • Full responsibility for maintenance and running of an automated liquid handler and internally developed instruments
  • Setup of new scripts to save time, simplify control, increase reproducibility, and minimize system errors
  • Experimental design for optimization of synthesis reaction parameters, for new reagent formulation (based on design of experiment, screening…) or new process
  • Perform in depth analysis of experimental data
  • Recruitment and management of a technician
  • Collaboration with external partners to develop new innovative applications for our technology
  • Regular presentation and reporting across all levels of the company
  • Actively contribute to critical company milestones, with a willingness to work outside immediate area of expertise when required

Qualifications and experience

Essential

  • Engineering degree in the field of biotechnology or PhD.  
  • 2 to 5 Years of experience in the field of biotechnology
  • Good knowledge in molecular biology, especially DNA related
  • Willingness to work on automated system, such as Hamilton or Tecan liquid handlers  
  • Basic coding skills (Python, Matlab, or others)
  • Ability to work as part of a multidisciplinary team 
  • Good level in English
  • Highly motivated and proactive
  • Excellent organizational, analytical, and systematic troubleshooting skills
  • Excellent communication and interpersonal skills 

Desirable

  • Good French speaker
  • Experience in working with polymerase
  • Experience in process optimization
  • Experience in working with liquid-handling robot such as Hamilton

Miscellaneous

Apply now

The Role

DNA Script is looking for a dynamic, talented individual to join the Company for an internship in image acquisition and image analysis of inkjet-printed droplets containing enzymes.

The intern will help improve a prototype printer for the synthesis of DNA microarrays by automating the image acquisition process. Currently, each cycle in the DNA synthesis process involves the printing of up to one million picolitre droplets followed by imaging and wet processing of the microarray substrate.

The aim of the internship will be to determine the individual positions and sizes of the droplets in under 3 minutes and identify missing, non-spherical and out-of-position droplets. Real-time reporting will allow corrective actions to be taken and post-synthesis quality metrics will enable DNA Script to determine whether any increase in product purity is due to improved print quality and/or process improvements such as more vigorous washing of the slide or a new ink formulation. If time allows, the intern will also help automate the whole synthesis cycle by linking together different pieces of software. 

The intern will receive an introduction to DNA Script and the prototype printer before conducting a short literature review and sourcing and installing any software and hardware deemed necessary to achieve the stated aims. He / she will be supervised by two PhD-qualified scientists with experience in optics and will interact with other members of DNA Script’s multidisciplinary team as needed.

Qualifications and experience

Essential

  • Last year of engineering school in the field of chemistry/biochemistry
  • Knowledge of image manipulation software such as Fiji (/ImageJ) and Gimp
  • Experience of programming tools and languages such as LabView, C/C++/C# is sought
  • Ability to work as part of a large multi-disciplinary team
  • Excellent learning, organizational skills
  • Highly motivated candidate with passion for science

Desirable

  • Hardware and optical imaging knowledge would be valuable though is not essential.
  • Good level in French and/or English

Miscellaneous

  • Job located in Kremlin-Bicêtre (Paris area)
  • Start date: As soon as possible
  • Compensation: 1200€ / month

Apply now

The role

DNA Script is looking for a dynamic, talented individual to join the Enzyme Engineering team as an Engineer. Your role will be to help us evolve proprietary enzyme variants and develop an optimized enzymatic reaction process within an exciting, high-profile(?) oligonucleotide synthesis project.

Responsibilities

•             Design mutagenesis libraries via structural understanding and bioinformatic tools

•             Perform cloning and PCR experiments to construct mutagenesis libraries

•             Express and purify enzyme variants in various scales from 96well plate to 1 L

•             Screen mutagenesis libraries by activity, stability, expression level and other features specific to our oligonucleotide synthesis process

•             Characterize optimized variants and validate their performance in multistep oligonucleotide synthesis experiments using liquid-handling robots

•             Develop assays for screening several enzyme features

•             Engagement in good laboratory practices

•             Support the team when needed

Qualifications and experience

Essential

•             Masters’ Degree in Biology, Biochemistry or Chemistry

•             ‘Hand on’ working experience in molecular biology or biochemistry lab

•             Familiarity with protein handling and purification

•             Familiarity with DNA handling and purification

•             Familiarity with protein structure and sequence analysis

•             Strong record keeping skills

•             Strong interpersonal skills

•             Good command of the English language

Desirable

•             Experience in directed evolution of proteins

•             Basic knowledge in Python scripting

•             Experience in working with liquid-handling robot

Miscellaneous

•             Job located in Kremlin-Bicêtre (Paris area)

•             Start date: ASAP

Contact: th@dnascript.co

Apply now

Mission

Dans le cadre de l’activité croissante du groupe ingénierie enzymatique, nous recherchons un(e) technicien(ne) afin de renforcer notre équipe de criblage enzymatique. Vous rôle sera de participer à la construction d’un processus de criblage robuste et à haut débit afin de sélectionner des enzymes évoluées pour la technologie de synthèse d’ADN.

Responsabilités

  • Surexprimer et produire des variants d’enzyme à petite échelle (en erlenmeyer)
  • Tester les variants d’enzyme purifiés en synthèse d’ADN automatisée
  • Préparer et réaliser des synthèses d’ADN automatisées
  • Réaliser de manière efficiente et reproductible des opérations quotidiennes
  • Aider à la réalisation des tâches communes dans l’équipe (préparation de solutions, milieux et de cellules compétentes)
  • S’engager dans de bonnes pratiques de laboratoire

Qualifications et expériences

  • Bac +2/3– formation BTS/DUT en biologie, biochimie ou biotechnologie
  • Expérience dans un laboratoire de biologie ou de biochimie
  • Être familier avec la surexpression et la purification des protéines
  • Bon niveau d’anglais
  • Esprit d’équipe et d’initiative
  • Apprécier le travail en laboratoire dans un environnement dynamique et multiculturel

Informations diverses

  • Poste basé au Kremlin-Bicêtre (94) – Ile de France – sortie Métro ligne 7
  • Date d’embauche : ASAP
  • Contrat : CDI à plein temps
  • Rémunération : à définir selon expérience

Contact : Merci d’envoyer votre CV à fj@dnascript.com

Apply now

Mission

DNA Script recherche un(e) Technicien(ne)Applications afin de tester, développer et optimiser ses produits à base d’ADN synthétique. Vous serez en charge d’exécuter des expériences utilisant les produits développés au sein de l’entreprise afin d’évaluer leur potentiel dans différents types d’applications de biologie moléculaire et de génomique. Votre travail contribuera également au développement de nouvelles approches et de nouveaux protocoles à même de changer l’expérience utilisateur dans de nombreux domaines des sciences de la vie. Votre activité et vos résultats auront un impact direct au niveau du développement produit et du marketing et seront cruciaux dans l’établissement de partenariats scientifiques et commerciaux.

Responsabilités

  • Contribuer au développement et à la validation d’applications utilisant les produits développés par DNA Script ;
  • Contribuer à la conception d’expériences et les exécuter de façon efficace et reproductible ;
  • Contribuer à la rédaction de notes d’applications par la production de rapports d’expérience de qualité ;
  • Contribuer aux bonnes pratiques de laboratoires en rédigeant des SOPs (protocoles d’utilisation) et en s’assurant de leur mise en application au sein de l’équipe ;

Qualifications et expériences

Essentielles :

  • Bac+2/BTS en Biotechnologie, Biologie Moléculaire
  • 3 à 5 ans d’expérience en R&D en biologie moléculaire dans le secteur industriel ou académique
  • Excellente connaissance des techniques de biologie moléculaire (Méthodes de purification et de caractérisation des acides nucléiques, PCR, qPCR, ddPCR, techniques de séquençage (Sanger, NGS), techniques d’édition de génomes (CRISPR…), CHIP, molecular probes)
  • Excellentes compétences en communication et relations interpersonnelles, le poste implique d’interagir avec de nombreuses personnes travaillant au sein d’équipes différentes
  • Excellentes compétences organisationnelles et analytiques
  • Personnalité motivée avec un fort intérêt pour les nouvelles technologies ; appréciant le travail sur automates et le développement technologique
  • Bonne maîtrise d’Office (Excel, Word et Powerpoint)
  • Dynamisme, réactivité
  • Bon niveau d’Anglais (équipe internationale)

Souhaitables :

  • Expérience de travail sur des systèmes automatisés de type robots pipeteurs (Eppendorf, Tecan, Opentrons)
  • Expérience de travail au sein d’équipes pluridisciplinaires
  • Expérience dans le domaine de la synthèse d’acides nucléiques
  • Expérience dans le séquençage d’acide nucléiques (Sanger ou NGS, préparation de librairie de séquençage)

Informations diverses

  • Poste basé au Kremlin Bicêtre (94) – Ile de France – sortie métro ligne 7
  • Date d’embauche : ASAP
  • Contrat : CDD d’un an

Apply now

The role

DNA Script is looking for a talented Bioinformatician to provide comprehensive bioinformatic support to its Application Development Team which is central to the development of the company’s core technology. Today, DNA Script’s Application Development Team main mission is to develop new innovative applications for our technology, involving the current use of sequence alignment, oligo design and Next Generation Sequencing (NGS) data, among others.

The candidate will be mainly in charge of leading the analysis and interpretation of high throughput sequencing datasets enabling the rapid evaluation of the applications under development. As such, the Bioinformatician will develop and apply bioinformatic methods and tools and perform tasks to help the Application team to interpret and prioritize their projects. In particular, the candidate will be in charge of developing:

  • Bioinformatic pipelines dedicated to the analyses of high throughput sequencing data
  • Tools for primer design

Bioinformatic analysis is central to the Application Development team therefore the candidate will need to interact with the different team members, understand their needs and develop the appropriate solutions.

We are looking for a person who is rigorous, methodical, well organized, detail-oriented, problem-solver and capable of playing a cross-functional role within a multidisciplinary team.

Qualifications and experience

Essential:

  • Master’s Degree/PhD in Bioinformatics or Senior Bioinformatician with 5+ years of significant computational experience related to bioinformatics work in academia, biotechnology, or other healthcare field involving next generation sequence data analysis
  • First-hand experience in NGS analysis and methods as well as the computing infrastructure and data management methods to support NGS
  • Perfect knowledge of:
    • Sequencing technologies and sound knowledge of the technical specificities inerrant to each of them (ie Illumina, PacBio, IonTorrent, Oxford Nanopore etc
    • Large dataset analysis in Python
    • Analyzing next generation sequencing data (DNA-seq, RNA-seq, etc.).
    • Building an NGS pipeline
    • Commonly used database and bioinformatics tools for NGS data analysis (e.g.) bedtools, SAMtools, IGV, ANNOVAR, Bowtie, GATK, ChimeraScan, UCSC Genome Browser, SoftGenetics, TopHat, etc.)
    • Proficiency in a scripting language (e.g. Python, 3.0) and Unix environments
  • Knowledge about molecular biology and genomics, ability to translate a biological question into a mathematical model/analysis method
  • Proven experience and success in a team-oriented environment
  • Feel comfortable in a fast-paced work environment
  • Excellent level of English and good level of French

Desirable:

  • First-hand experience at integrating publicly or commercially available genetic, genomic, and interaction datasets with novel experimental data to identify testable hypotheses
  • HTML/CSS, Javascript and SQL on NoSQL databases
  • Web framework (e.g. Django, etc)

Miscellaneous

  • Job located in Kremlin-Bicêtre (Paris area, 5minutes from Porte D’Italie)
  • Start date: ASAP
Apply now

The role

DNA Script is looking for a highly motivated, well organized team-player to join the Enzyme Engineering team as a Technician. Your role will be to help us evolve proprietary enzyme variants within an exciting, high-profile oligonucleotide synthesis project.

Responsibilities

•             Express and purify enzyme variants in various scales from 96well plate to 1 L

•             Screening of mutagenesis libraries applying multiple assays

•             Isolate plasmid DNA and determine mutant sequences

•             Participate to the characterization of optimized variants

•             Prepare buffer and reagent stocks needed for the project and perform QC tests prior to usage when needed

•             Keep very good record of experimental data

•             Engagement in good laboratory practices

•             Support the team when needed

Qualifications and experience

Essential

•             Bachelors’ Degree in Biology, Biochemistry or Chemistry

•             ‘Hand on’ working experience in molecular biology or biochemistry lab

•             Familiarity with protein handling and purification

•             Familiarity with DNA handling and purification

•             Familiarity with protein structure and sequence analysis

•             Strong record keeping skills

•             Strong interpersonal skills

•             Good command of the English language

Desirable

•             Experience in directed evolution of proteins

•             Experience in working with liquid-handling robot

Miscellaneous

•             Job located in Kremlin-Bicêtre (Paris area)

•             Start date: ASAP

Contact : th@dnascript.co

Apply now

The role

DNA Script is looking for a talented chemist/biochemist to strengthen its Analytics platform which is an important part of the Development team. The role will be at the crossroad of surface chemistry and analytics providing the team with a novel vision and understanding of their process.

The candidate will be mainly in charge of:

  • Developing analytical methods to characterize modified oligonucleotides produced by enzymatic DNA synthesis
  • Study solid supports used for DNA synthesis and their role at different stages of the synthesis process by optical/confocal microscopy

We are looking for a person who is rigorous, methodical, well organized, detail-oriented, problem-solver and capable of playing a cross-functional role within a multidisciplinary team.

Responsibilities

  • Develop optical methods for the characterization of fluorescent/non-fluorescent oligonucleotides, including PCR/qPCR probes
  • Implement confocal microscopy as new characterization tool for solid supports used for DNA synthesis
  • Perform routine analysis of modified DNA and solid supports
  • Design and conduct experiments to support R&D projects
  • Help enrich analytical platform with instruments suitable for our R&D departments
  • Write analytical protocols and analytical development reports
  • Participate in the scientific and technical state of the art review

Qualifications and experience

Essential

  • Master 2 or Engineer in Chemistry/Biochemistry or any related field
  • Hands-on experience with optical characterization of biomolecules (UV-Vis, fluorescence, FRET, …)
  • At least 3 to 5 years of hands-on experience with optical microscopy / confocal microscopy
  • Ability to design, execute, interpret, and troubleshoot experiments
  • Excellent verbal and written communication, strong organizational and interpersonal skills
  • Highly motivated, passionate about developing tools and methods
  • Ability to work independently and within a large multidisciplinary team
  • Excellent level of English and good level of French

 Desirable

  • First significant experience in laboratory and biotechnology environment
  • Experience with fluorescent DNA probes (qPCR/TaqMan)
  • Familiar with image analysis software (ImageJ, …)

Miscellaneous

  • Job located in Kremlin-Bicêtre (Paris area)
  • Start date: ASAP

Apply now

Mission

DNA Script is looking for a R&D Fermentation Engineer to reinforce the development and production of its proprietary enzymes. You will join the enzyme production team composed of 6 persons and support the fermentation activities under the supervision of the USP leader.  You will be in charge of optimizing the fermentation process of different enzymes in bioreactor from lab scale to pre-pilot scale in order to increase the production yield of those enzymes.  You will also manage strain optimization by using conventional molecular biology tools. You will participate to the production of enzyme batches in order to support R&D activities.

Responsibilities

  • Participate in the implementation of the optimization and production strategy
  • Conduct fermentations at different scales in bioreactors in autonomy
  • Perform optimizations in plates, flasks and bioreactors (500 ml to 30 L)
  • Ensure the quality and analytical monitoring of fermentations
  • Analyze, report and present the results
  • Suggest areas for improvement in order to increase the productivity of the enzymes produced
  • Manage strain optimization (construction, evaluation and storage of strain collection)
  • Conduct experiments by following laboratory procedures and GLP
  • Participate in the common tasks of the fermentation team: management of stocks and reagents (medium, strain, plasmid, petri dish), weekly cleaning

Qualifications and experiences

  • Holds a Master or an engineer degree in the field of biotechnology
  • At least 2-3 years of experience in fermentation
  • Knowledge in the implementation of experience plan (DOE)
  • Experience in the production of recombinant proteins and in protein expression screening in microtiter plate format
  • Experience in operating bioreactors in batch, fed batch and continuous culture mode
  • Experience in soluble/insoluble protein extraction as well as SDS-PAGE analysis
  • Skills in molecular biology (cloning, vector design) will be appreciated
  • Experience in colorimetric assays for the analysis of metabolites and substrates
  • Proactive with team spirit
  • Appreciate lab work in a dynamic and evolving environment
  • Good writing and synthesis skills
  • Good level of English
  • Knowledge in French

Miscellanous

  • Job located in Kremlin-Bicêtre (Paris area, 5 minutes from Porte d’Italie)
  • Start Date: Jan-Feb 2021
  • Contact: send your resume to ab@dnascript.com
Apply now

The role

DNA Script is looking for a talented Mass Spectrometry Specialist to strengthen its Analytics platform which is an important part of the Development team. Today, DNA Script’s analytical platform has two main missions:

  • A mission of service by analyzing all the synthesis samples and proprietary reagents of the R&D teams, mainly by LC-MS and capillary electrophoresis
  • A mission of development and continuous improvement of analytical techniques responding to the daily and specific need of all the R&D and more and more of the product development team members.
    The candidate will be mainly in charge of leading the Mass Spectrometry (LC-MS) instruments within the analytical platform, conducting analyses and method development with a new high-resolution mass spectrometer and developing analytical methods in support of R&D.
    As the analytics platform is central to R&D teams, the candidate will have to interact with many different teams, understand their needs and develop appropriate analytical solutions.
    We are looking for a person who is rigorous, methodical, well organized, detail-oriented, problem-solver and capable of playing a cross-functional role within a multidisciplinary team.

Responsibilities

  • Help evaluate, choose, install, and qualify a new LC-High-Resolution MS system
  • Develop analytical methods for R&D projects (sample preparation, methods of analysis, quantification method, etc.)
  • Conduct data analysis/interpretation to support R&D with analysis of nucleotides and oligonucleotides and provide comprehensive reports to non-Mass specialist
  • Ensure routine maintenance of the mass spectrometers including a newly acquired instrument (HR-MS), and existing instruments UPLC/single-quad system, as well as interfacing with vendors for instrument repair, when required
  • Be accountable of the analytical results quality, provide KPI and metrics to assess result quality and methods limitation
  • Work in close relationship with the synthesis platform in developing new high throughput analytical methods for oligonucleotides and contaminants characterization
  • Perform specific one-shot analysis for very specific demand providing deep understanding to certain specific questions
  • Communicate results by performing presentations, writing reports and SOPs
  • Perform regular state of the art studies on new innovative analytical methods, stay informed on new commercial products and upgrade

Qualifications and experience

Essential

  • PhD in Analytical Chemistry (Mass Spectrometry) or Senior Engineer with 10+ years of relevant experience
  • Demonstrated aptitude in biomolecule mass spectrometry, preferably oligonucleotides
  • Perfect knowledge of UPLC-MS and MS/MS techniques and associated software.
  • Ability to design, execute, interpret, and troubleshoot experiments
  • Excellent verbal and written communication
  • Strong organizational and interpersonal skills
  • Highly motivated, passionate about developing tools and methods
  • Ability to work independently and within a large multidisciplinary team
  • Excellent level of English and good level of French

Desirable

  • Experience in MS analysis of oligonucleotides
  • Experience with LIMS
  • Experience in an ISO 13485 accredited laboratory
  • Experience in Electrophoresis capillary or other analytical methods

Miscellaneous

  • Job located in Kremlin-Bicêtre (Paris area, 5 minutes from Porte d’Italie)
  • Start date: ASAP
Apply now

The Role

DNA Script is looking for a dynamic, talented individual to join the Nucleotide Chemistry team for an
internship in synthesis of modified nucleotides. The project consists in performing multistep synthesis
for different modified nucleotide targets. Those nucleotides will be then tested using our enzymatic
DNA synthesis technology to synthesize modified DNA for different types of application. The internship
will be supervised by a confirmed PhD in organic chemistry.

Qualification and Experience

Essential

  • Last year of engineering/ master degree in the field of organic chemistry
  • Good knowledge and practice in organic reaction, purification utilizing chromatography
  • techniques and analysis of organic molecules by TLC, NMR, HPLC, LC/MS
  • Ability to work as part of a large multi-disciplinary team
  • Good level of English
  • Excellent learning, organizational skills
  • Highly motivated candidate with passion for science

Desirable

  • Experience on nucleoside/nucleotide chemistry

Miscellaneous

  • Job located in Kremlin-Bicêtre (Paris area)
  • Start date: As soon as possible
Apply now

The role

DNA Script is looking for a dynamic, talented individual to join the surface chemistry team for an internship in DNA probe synthesis.

The mission consists in developing methods and protocols for the preparation of DNA probes, including TaqMan probes, for qPCR assays. The intern will be in charge of modifying short DNA sequences (oligonucleotides) with a wide range of modifications (fluorophores, quenchers, biotin, etc.), via different coupling chemistries. He/she will also characterize the probes by UV/fluorescence spectroscopy, qPCR, and other analytical techniques. The internship will be supervised by the Team Leader a confirmed PhD in Chemistry.

Qualifications and experience

Essential

  • Last year of engineering school in the field of chemistry/biochemistry
  • Good knowledge in organic chemistry, in particular with biomolecules (DNA, proteins)
  • Good understanding of PCR/qPCR techniques
  • Good knowledge of UV and fluorescence spectroscopy
  • Excellent learning, organizational and analytical skills
  • Ability to work as part of a large multi-disciplinary team
  • Highly motivated, with a passion for new technologies

Desirable

  • Good level in French and/or English
  • Experience in bioconjugate chemistry
  • Experience in PCR/qPCR
  • Experience with solid supports (micro/nanoparticles)

Miscellaneous

  • Job located in Kremlin-Bicêtre (Paris area)
  • Start date: As soon as possible
Apply now

The role

DNA Script is looking for a talented molecular biologist, in a role that is central to the development of the company’s core technology.  The candidate will be responsible for managing a team of 3 to 5 scientists/engineers ensuring excellent quality work, good people and project management, organization and good communication with the Business development and marketing team. 

He or she will be in charge of interacting with external partners or future customers to provide them with thoroughly qualified oligos for their application. She or he will be developing new innovative application for our technology and produce application notes to open new markets in collaboration with marketing. These developments will have a direct impact on the R&D and product development process.

Responsibilities

  • Manage the Application Development Team, ensuring efficient organization, quality and thorough analysis of data, good communication and team spirit
  • Ensure good communication with partners and customers in particular in understanding their needs and providing data based on current synthesis and characterization methods hand in hand with Business Development and Marketing
  • Help with support to customers: understand their assays and results to help them troubleshoot if needed
  • Provide excellent quality documentation and reporting of experimental findings for internal and external use.
  • Provide technical presentation and Application notes for Marketing. 
  • Develop new applications based on the Business development or marketing feedback or on innovative idea taking advantage of unique aspects of our technology 
  • Engagement in good laboratory practices
  • Active contribution towards critical company milestones and strategy, with a willingness to work outside immediate area of expertise where required
  • Technology watch on new DNA uses and trends in market
  • Represent the company to the external world

Qualifications and experience

Essential

  • PhD in the field of molecular biology, biological process engineering, biotechnology or similar, 
  • Minimum of 10 years’ experience in R&D after PhD graduation (molecular biology, diagnostics, or a related field) with excellent laboratory skills and experience of common molecular biology methods such as nucleic acid isolation, quantification, PCR/qPCR, CRISPR, NGS library preparation, etc
  • Experience of application development in an industrial environment
  • Positive experience of management for at least 3 years after PhD graduation
  • Fluent in English with excellent writing and presenting skills
  • Ability to work efficiently and as part of a large multi-disciplinary team
  • Excellent communication and interpersonal skills
  • Excellent organisational, analytical, and systematic troubleshooting skills
  • Highly motivated, with a passion for new technologies 

Desirable

  • Some notion in French
  • Have some experience in field application support

Miscellanous

  • Job located in Kremlin-Bicêtre (Paris area)
  • Start date: ASAP
Apply now